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KMID : 0379119950230040285
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Korean Journal of Mycology
1995 Volume.23 No. 4 p.285 ~ p.297
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The Composition and Bioactivities of Ganoderan by Mycelial Fractionation of Ganoderma lucidum IY009
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이준우/Lee, June Woo
정훈/한만덕/김수웅/윤경하/백성진/Jeong, Hoon/Han, Man Deuk/Kim, Su Ung/Yoon, Kyung Ha/Back, Sung Jin
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Abstract
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Ganoderan, an immunomodulating β-glucan of G. lucidum, induces potent antitumor immunity in tumor-bearing mice. The present study was set up to elucidate the chemical composition and bioactivities of ganoderan obtained from the mycelial fractionation of G. lucidum IY 009. Ganoderan was isolated and purified from its extracellular, cell wall and cytoplasmic sources. These ganoderans were composed mainly of glucose. The cell wall-alkali soluble-water soluble fraction (CW-AS-WS) showed the highest antitumor activity (inhibition rate of 94%) in sarcoma-bearing mice and 37% of anticomplementary activity. The CW-AS-WS fraction was found to be approximately average 20,000 dalton in ad. 0.3N NaOH solution and composed of 88% carbohydrate and 4% protein. The carbohydrate of the CW-AS-WS was composed of 74% glucose. These results indicate that the ganoderans extracted from the mycelial fractionations of G. lucidum IY009 bad different chemical characteristics and showed different potentiality in antitumor and anticomplementary activity.
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